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In some embodiments, the otic pharmaceutical formulation comprises about 58% by weight of the triglycerides

This is a known consideration in freeze-dried and frozen formulation research, where excipients such as mannitol are studied specifically to protect molecules through these phase changes, as covered in the Journal of Pharmaceutical Sciences review cited above

It has been shown to promote satiety and reduce food intake

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These results, which suggest that D-Nle- Tyr-Ile-NH-(CH 2 )5-CONH 2 is likely to be relatively hydrophobic, are in agreement with the outcome of QSAR modeling estimates generated by ADMET Predictor that calculated an octano water partition coefficient of 28.18 for D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 (Table 6)