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Therefore, we propose a rational conceptual framework: the periconception metabolic optimization tool

The authors report no outside funding

new research highlights that device acceptability significantly depends on user-friendly design, low discomfort, ease of use, and evident therapeutic results

Evolution of clinical outcome measures and biomarkers in sporadic adult-onset degenerative ataxia

The optimal strategy depends on individual response, side effect tolerance, and practical considerations including cost

This pharmacologic property distinguishes it from small-molecule therapeutics where hepatic impairment dramatically alters drug-drug interaction profiles