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Clinical trials for semaglutide have shown fatigue as a side effect, but its usually temporary

Semaglutide is a GLP-1 receptor agonist that primarily acts on receptors in the brain (appetite regulation), pancreas (insulin secretion), and gastrointestinal tract (gastric emptying)

Injections may also cause mild pain or discomfort at the injection site

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While most participants in that study had diabetes, the cardiovascular protection extended to blood pressure metrics and overall heart health markers

Patients with hypothyroidism frequently experience weight gain, fatigue, and difficulty losing weight even with dietary modifications and exercise