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Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

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Tirzepatide follows the same pattern: Mounjaro: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg for type 2 diabetes Zepbound: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg for obesity The doses are identical

Wang J, Fan S, Xiong Q, Niu Y, Zhang X, Qin J, Shi Y, Zhang L (2021) Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways

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