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Demographics: The Gender Gap Recent meta-analyses, including a significant March 2026 study from Johns Hopkins , have revealed that biologyspecifically sex hormonesplays a major role in response rates

PMID 15010535

TRIUMPH-4 was a randomized, phase 3, 68-week study

Part of that difference comes down to a hormone most people have never heard of: GLP-1

Early Treatment Phase: Why Some Patients Feel Fatigue Before Improved Energy During weeks 14 of tirzepatide initiation or dose increase, some patients experience transient fatigue or reduced motivation