The route simply adds a short-term local component on top of the same systemic effects
This can cause a strain on your liver, kidneys, and other organs used in the removal of waste products, using them more than they need to
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For example, consuming a nutrient preload prior to the main meal has been shown to reduce postprandial blood glucose in both health and type 2 diabetes by stimulating GLP-1 secretion in advance of the meal, and by slowing gastric emptying (81, 82)
Leptin treatment improves insulin resistance and hyperglycemia in a specific mouse model of type 2 diabetes MKR (transgenic overexpression of a skeletal muscle dominant-negative IGF-I receptor with a lysine-to-arginine amino acid)