The effects of sodium-glucose cotransporter 2 inhibitors on adipose tissue in patients with type 2 diabetes: a meta-analysis of randomized controlled trials
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So I wrote a little thing for @MolMetab sciencedirect.com/science/articl As we now appreciate, GLP-1 can target multiple brain regions and neuronal populations to reduce food intake, and the clinical results are increasingly impressive #obesity The ongoing SELECT trial will be pivotal for the field sciencedirect.com/science/articl From very modest weight loss with exenatide twice daily, the GLP-1 field has learned, by titration, dose escalation, higher Cmax, and better molecules, to achieve clinically meaningful #weightloss #T2D #obesity More progress to come #obesity described here sciencedirect.com/science/articl Beyond semaglutide and tirzepatide, where might we find the next GLP-1-based advances in #weightloss #obesity Take a look at the slope of the lines for the combination of cagrilintide + semaglutide and make projections out to 52 weeks thelancet.com/journals/lance Join the conversation

Stay Hydrated Semaglutide can cause dehydration because it slows digestion and reduces appetite, leading some people to drink less water
Other known antioxidant defense mechanisms are superoxide dismutase enzymes and catalase that turn superoxide anions into water (1, 2)
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