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Subsequently, 100 L of CCK8 working solution (10 g/mL) was added and incubated for an additional 1 h, and the absorbance was measured at 450 nm using a microplate reader (Varioskan LUX)

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It is well affirmed from recent experimental findings that interleukin 6 (IL-6) signaling via STAT-3 contributes to repression of foxp3 transcription, so the probable repression of IL-6 signaling by statins may indirectly support foxp3 expression, leading to an improved proportion of Treg cells [62]

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The A subunit is encoded by the MT-ATP6 gene and the A6L subunit is encoded by the MT-ATP8 gene