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Statistical analyses Data are graphed as the mean SD (refer to figure legends for detailed information) and P value were determined by unpaired Students t-test (two-tailed), one-way or 2 way ANOVA using Prism (GraphPad version 9.0.1)

A history of severe allergic reactions to injectable antioxidants warrants extreme caution or complete avoidance

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Starting two or three times a week lets skin adapt

In direct comparison, GHK-Cu improved collagen production in 70% of treated women, compared to 50% with vitamin C cream and just 40% with retinoic acid

Acknowledgments This study was made possible by funding from National Institutes of Health R01AR060366 & R21AI094377