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Skeletal muscle can release medium-chain acylcarnitines (MCACs) into the circulation to remove acyl-CoA, which can be detrimental to cellular function, particularly when the supply of energy substrates exceeds the oxidative capacity of the TCA cycle

In a proof-of-concept human trial, three months of supplementation with pasteurized Akkermansia was safe and well tolerated and improved insulin sensitivity ( Depommier et al., 2019 )

doi: 10.1016/j.molmed.2020.11.003 64 CapalboAHoffmannERCimadomoDUbaldiFMRienziL

GPX4-independent pathways, including FSP1/CoQ10, DHODH, and GCH1/BH4, all contribute significantly [56,60-62] (Figure 1)

Eli Lillys pending approval, combined with emerging nextgeneration incretin candidates, ensures that the race for leadership in obesity care is far from settled