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Lipodystrophy can alter absorption rates, making the same dose less predictable over time

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Although the body can destroy free radicals naturally, a build-up can occur due to an unhealthy diet, aging, smoking, mental stress, sun exposure, and exposure to environmental pollutants

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Moreover, nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib, a selective COX2 inhibitor, that is the most commonly used drug in the treatment of arthritis, was embedded in niosomal gel for the purpose of sustained and site-specific delivery Kaur and colleagues