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In vitro studies suggested that genistein treatment of human keratinocytes and fibroblasts modulates glutathione content and reactive oxygen species release, endothelial/inducible (e/i)NOS dependent nitric oxide release, MMP expression, and mitochondria membrane potential through mechanisms involving p38 MAPK, AKT and ERK1/2 as downstream signaling associated with membrane ERs and GPER, as well as by increasing SOD activity and BCL2 expression in endothelial cells (Savoia et al., 2018

Cellular Health : By maintaining cellular integrity, glutathione contributes to the overall health of tissues and organs

10.3389/fneur.2012.00003

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2 GSTP1 is not only involved in cancers, but also in other diseases

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