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A 2021 pilot study published in Hepatology International found that participants with biopsy-confirmed NAFLD using weekly lipotropic injections alongside dietary modification showed mean reductions in liver fat content of 18% over 16 weeks measured by MRI

The more relevant research question is whether triple receptor agonism (GIP + GLP-1 + glucagon) combining elements of both approaches could outperform either dual agonist

Similarly, tirzepatide dose escalation from 5 mg to 7.5 mg, 10 mg, or even 15 mg can break through plateaus

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Vahjen et al., 2010