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For weight management (NICE TA875 for semaglutide 2.4mg/Wegovy and TA664 for liraglutide 3mg/Saxenda): Treatment should be discontinued if specific weight loss targets are not met (typically at least 5% of initial body weight at 12-16 weeks)

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and various animal models bearing modifications in ER UPR-associated functions demonstrate defects in pancreatic cells and impaired glucose metabolism (131134)

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Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

And like any powerful tool, they must be used intentionally