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As a reaction to the high variability in intrapatient trough levels, which are associated with worse outcomes (124129), once-daily administered Tac formulations with prolonged drug release have been developed to improve bioavailability and adherence as well as lower intraday fluctuation and peak concentrations (Cmax), as illustrated in Figure 1
doi: 10.3315/jdcr.2014.1175 74 ElderDEBastianBCCreeIAMassiDScolyerRA
For comparison, glucagon secretion in the intact mouse pancreas perfused at the physiological rate (~0.3 ml/min) measured at 1 mmol/l glucose using the same assay was 8617 pg/min ( n =10) (i.e
To put those numbers in human terms, a 220-pound person on the highest dose would lose approximately 50 pounds over the treatment period
K.CoskunT.YucelD.KaracaM.SivriH