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Observational studies and some ophthalmology commentaries have been more reassuring overall, suggesting that many patients taking semaglutide do not experience clinically meaningful retinal worsening

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For example, in contracting skeletal muscle tissue, the sarcoplasmic reticulum Ca 2+ -ATPase (SERCA) facilitates calcium reuptake into the reticulum, preventing calcium overload in the sarcoplasmlikely in synergy with HSPA5 (Mzala et al., 2024)