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Arch Med Res 34(2):8999

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Through the activation of AMP-activated protein kinase (AMPK) and other energy-sensing pathways, MOTS-c enhances fat oxidation, glucose utilization, and metabolic resilience

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Patients were to have an HbA1c of 7% to 10% and be treated with metformin, a sulfonylurea, or a glitazone as single agent or in any combination, or with a reduced-calorie diet and physical activity alone

Hold your breath for about 10 seconds, then exhale