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If you experience difficulty or pain when swallowing food, it can be due to problems in the esophagus, such as esophageal stricture and achalasia

The critical management task is distinguishing expected pharmacodynamic discomfort from signals that warrant dose pause or permanent discontinuation

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All methods were reported in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines ( ensuring transparent and comprehensive reporting of experimental design, animal husbandry, experimental procedures, sample size, statistical methods, and ethical considerations

After the initial dose escalation phase (weeks 4-10), side effects dropped dramatically

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury