Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)
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[43],[44],[45],[46],[47] In addition, there is sufficient evidence demonstrating the importance of glutathione levels in the genesis of melanoma and related skin tumors
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The last involves oxygen reduction and is a process that can act to balance chloroplast ATP:NADPH ratios or function as an alternative sink for electrons but which also generates ROS as intermediates (Allen and Hall 1974
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