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Even when late-stage data look strong, the FDA still reviews efficacy, adverse events, manufacturing, labeling, contraindications, drug interactions, and risk-management requirements

Kisspeptin, which has been used in trials to trigger ovulation, acts on the hypothalamic-pituitary-gonadal axis and can cause safe, physiologic LH surges for assisted reproduction

Investigators have used bulk quantities of GSH purchased from various chemical companies

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Inhibition of chondrogenesis by parathyroid hormone in vivo during repair of full-thickness defects of articular cartilage

That is, for each numerator component, the denominator includes all ED encounters associated with patients of all ages, for all-payers, during a 12-month period of performance, and the numerator includes the ED encounters in the denominator that met the criteria for the designated numerator event