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Author contributions KM and DW planned the experiments

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Intravascular volume depletion, a dose-dependent increase in serum creatinine and a known marker of renal damage are also discovered in SGLT2 inhibitors treatment in patients with T2DM [70]

Concurrent Use of Alcohol and Other Central Nervous System Depressants Patients should be advised to avoid concurrent use of RYALTRIS with alcohol or other CNS depressants because additional reductions in alertness and additional impairment of CNS performance may occur [see Warnings and Precautions (5.2)]