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The effect of 2.4 mg once-weekly injected semaglutide in patients with HFpEF, obesity and T2D is currently investigated in an ongoing trial STEP-HFpEF DM (Semaglutide Treatment Effect in People with obesity and HFpEF and type 2 diabetes) (64, 65)

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58 Thus, we further explored mechanistically the interplay between oxidative stress and AA levels in terms of DAT function

Importantly, GLP-1 receptor agonists are not recommended for patients with severe gastroparesis, as they may further delay gastric emptying and worsen symptoms