On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes
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Moreover, the different adipose stem cell types can stimulate or inhibit adipogenesis
As a powerful antioxidant, it helps protect immune cells from oxidative damage so they can function optimally
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L-Carnitine has been shown to support the integrity of the skin barrier by enhancing the production of ceramides, fatty acids, and other lipids that contribute to its structural integrity