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Free heme induces neuroinflammation and cognitive impairment by microglial activation via the tlr4/myd88/nf-b signaling pathway

K.et al (2018)

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This raises the crucial question of whether NERNST really reports cytosolic NADP redox state in vivo or whether its specificity is compromised by equilibration with E GSH as catalysed by the endogenous glutaredoxins (Grx)