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This difference may be due to the estimand choice of Pan et al., which is not reported, and the influence of additional studies that did not match our target population as Pan et al.s NMA had much broader eligibility criteria, with some studies including participants with T2D or using intensive behavioural therapy

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These practitioners specialize in obesity medicine, bringing expertise that general practitioners may not possess regarding weight management protocols

doi: 10.1016/j.mce.2013.06.002

Many of these products are also temperature-sensitive, adding further complexity to cold chain logistics

Most users report noticeable appetite suppression beginning around week 3-4, with peak side effects occurring during weeks 6-8 before substantially improving by month 3