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In a cross-sectional study carried out in Moscow, it was shown that there is a significant negative linear correlation between serum MDA levels and riboflavin intake ( Reference Kodentsova, Vrzhesinskaia and Beketova 44 )

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Oxidative stress from pollution, smoking, and chronic inflammation can also stimulate melanin production by activating tyrosinase

Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87