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Systemic regulation of iron metabolism primarily occurs in the liver, where hepcidin binds to FPN, leading to its degradation and inhibition of iron export, thereby contributing to intracellular iron accumulation [99]

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When free radicals overwhelm the body's antioxidant defenses, oxidative stress occurs, leading to cellular damage that can contribute to various health issues, including: Aging Heart disease Diabetes Cancer Why Vitamin E

doi: 10.1152/ajpgi.00304.2014 162 Tosello-TrampontA-CLandesSGNguyenVNovobrantsevaTIHahnYS

Global burden of 369 diseases and injuries in 204 countries and territories, 19902019: A systematic analysis for the global burden of disease study 2019

doi:10.1177/0748233707077431