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TLDR: GLP-1s are a massive, fast-growing drug class for type 2 diabetes and weight loss

Oral semaglutide (Rybelsus) requires specific administration instructions: it must be taken on an empty stomach before the first food, beverage, or other oral medications of the day, with no more than 4 ounces of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications

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So how do they work

Back Hoet, JP (1953) 'Gustave Eduoard Laguesse: His demonstration of the significance of the Islands of Langerhans', Diabetes , 2,4, 322-24

Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes