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10.1523/JNEUROSCI.2830-19.2020 139 LiuX.SullivanK

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Rather than treating ferroptosis as a uniform vulnerability, clinical translation will probably succeed where patients can be stratified by (1) the architecture of antioxidant defenses (for example, FSP1/GPX4 balance), (2) the size and distribution of cellular CoQ pools, (3) lipid composition and peroxidation-prone membranes and (4) oncogenic programs that remodel redox metabolism (such as NRF2KEAP1)

Central nervous system effects: GLP-1 receptors are present in the brain, and their activation is hypothesised to influence neurological pathways associated with energy levels and alertness, though this mechanism has not been fully established in humans

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New York, NY: Springer (2011)