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The Right Starting Point The trial data is compelling

Pigmentation changes are rare but possible, particularly with higher doses or extended use

doi: 10.1161/01.RES.0000088786.19197.E4

The mechanism is straightforward: MC1R activation on melanocytes upregulates tyrosinase activity, driving conversion of tyrosine to eumelanin (the dark, photoprotective form of melanin)

Two percent provides meaningful activity without overwhelming the sensitive tissue around the eyes

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