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In cells harboring mitochondria with active tricarboxylic acid cycle (including platelets), the situation is more complex because mitochondria are themselves a source of endogenous ROS as byproducts of the electron transport chain [47]

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Moreover, these mice demonstrate a complex gastrointestinal phenotype involving mucosal inflammation, also associated with remarkable dysregulation of the mucosal epithelial homeostasis

Ferroptosis in fibroblasts is caused by a number of important processes and regulatory variables

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CM: Conceptualization, Supervision, Validation, Writing original draft, Writing review and editing