GLP-1s also activate receptors in the hypothalamus area of the brain (the control center for hunger and thirst) to curb appetite
In both instances, the goal of organ protection with SGLT2i or GLP-1 RA should be independent of background glucose-lowering therapies, current HbA 1c level or target HbA 1c level (Figs 3, 4)
doi: 10.1038/srep03273 80 McCarthyE.BarronA.Morales-PrietoN.MazzocchiM.McCarthyC
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Zepbound is designed to regulate glucose, and while it rarely causes hypoglycemia on its own in people without type 2 diabetes, adding berberine changes the equation