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These can range from leaky gut and inflammatory bowel disease to mast cell activation syndrome (MCAS) and anxiety, contributing to neurological dysfunction

The positive control used was topiroxostat, which showed an IC 50 of 17 nM, very close to compound 72 , the most active compound in the study (Figure 23)

HPA, hypothalamic-pituitary-adrenal

In the mid-2000s, Novo Nordisk had developed a peptide called liraglutide that mimics the gut hormone glucagon-like peptide-1 (GLP-1), leading to antidiabetic effects and weight loss

10,11 In recent years, research on ARDS has gradually increased, and understanding of ARDS has deepened

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