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Evidence on B12 Supplementation During GLP-1 Therapy Clinical trials of semaglutide for weight loss (the STEP trials with over 4,500 participants) did not routinely pair semaglutide with B12 injections or measure specific B12 supplementation outcomes

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Korhonen et al., 2018)

While C and S drive weight loss by reducing energy intake (EI) 11,14,15 , it is less clear whether they also affect energy expenditure (EE)

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Make sure the ones you buy are fortified with B12 but remember to take a supplement too