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Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death

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Numerous studies have demonstrated that several factors contribute to doxorubicin-induced acute cardiotoxicity, with oxidative stress and cell death being the most significant [85, 86]

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311 Such findings point towards different roles and different effects of reactive astrocytes at different times during the progression of autoimmune inflammation and suggest that different therapeutic approaches involving astrocytes may be required at different times