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Generalised mixed models with repeated measures were used to examine mean changes in clinical and laboratory parameters at baseline, 3 months, 6 months, and 12 months

Chronic exposure to loop diuretics induces structural and functional changes in the distal nephron, including hypertrophy and hyperplasia of epithelial cells, upregulation of sodium-chloride cotransporters, and activation of the epithelial sodium channel (ENaC)

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The study, which was published in American Journal of Ophthalmology , analyzed data over about a three-year period from 71 US healthcare organizations of 41,850 patients who initiated tirzepatide and 147,828 patients who initiated selective GLP-1 drugs

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