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[1] [2] The extent of human milk transfer, bioavailability to the infant, and potential systemic effects remain unknown

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Novo Nordisks Peter Johannsen, MD, highlighted the biological signals observed and acknowledged the clinical limitations: subgroup analyses did not reveal meaningful benefit, and any potential responder group would be very small

IDO-1 is found in various immune cells, including dendritic cells and macrophages, where it suppresses immune function by depleting tryptophan an amino acid vital for T-cell activity and generating immunosuppressive byproducts such as kynurenine