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The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose

Human trials are needed

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The injectable versions (Ozempic and Wegovy) are more commonly prescribed and available, but oral semaglutide known as Rybelsus offers an alternative for those who prefer to avoid injections

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This approach maintains more consistent beta-3 receptor stimulation throughout the 24-hour period