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Proper injection technique matters significantly: holding the pen perpendicular to the skin, injecting steadily rather than jabbing, and avoiding injection into areas with bruising or irritation all lower discomfort risk

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The flexible dose-adjustment approach allowing patients to escalate or de-escalate doses of the drug on the basis of their HbA1c and gastrointestinal tolerability (PIONEER-7) aimed to individually optimize efficacy and safety of once-daily oral semaglutide in T2D adults uncontrolled with one or two oral glucose-lowering drugs, compared to 100 mg/day of sitagliptin

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