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The genes for these and other phase II enzymes contain AREs and are therefore under the control of Nrf2 (see Antioxidant activity)

ROS can further activate epithelial cells and macrophages facilitating neutrophil, monocyte, and lymphocyte recruitment, and the recruited activated inflammatory cells subsequently enhance additional ROS generation, increasing the pro-oxidant burden (8085)

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Nonetheless, the possible benefits of urolithin A Mitopure or not are mainly due to the potential for the compound to activate a process in the body called mitophagy (mitochondrial autophagy)