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Because GLP-1 therapies delay gastric emptying, temporary discontinuation is recommended prior to procedures requiring anesthesia to reduce aspiration risk [32]

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The date of first use should be recorded on the vial, and the medication should be discarded after the specified period following initial puncture, typically 28 days, even if medication remains and the beyond-use date has not been reached

Altered miRNA profiles have been reported in the cochlea following acoustic trauma, and in tinnitus models induced by other etiologies such as salicylate, suggesting that miRNA dysregulation may contribute to maladaptive responses to peripheral injury (Patel et al., 2013)

Statistical analysis The integrated AUCs (iAUCs) for plasma glucose, insulin and total GLP-1 in response to intraduodenal glucose infusion between t = 0 min and t = 120 min were calculated by using the trapezoidal rule and subtracting the baseline area