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Recently, Chen et al (187) developed a folic acid-decorated, manganese dioxide-coated mesoporous silica nanoparticle to co-deliver fluvastatin sodium (MCT4 inhibitor) and metformin, effectively targeting tumor lactate metabolism by promoting lactate production and inhibiting lactate efflux, thereby exacerbating intracellular acidosis and inducing cancer cell death

PMC 9066945

H., Taga, M

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The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida

Wang, H., Xue, W