Additionally, metformin has been shown to be well-tolerated in patients with active cancer, making our outcomes more meaningful by comparison. In a subanalysis, researchers matched 1,620 adults with type 2 diabetes on metformin who were newly starting a GLP-1 with those on metformin who were newly starting insulin up to 3 months before or after initiating systemic cancer therapy
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These mechanisms are still being investigated, but existing data suggests that GLP2-Ts multi-receptor engagement may provide broader insights into obesity, insulin resistance, and related metabolic disorders compared to single-pathway compounds