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Ongoing research studies are testing the medication for obstructive sleep apnea (OSA), knee osteoarthritis (OA), non-alcoholic fatty liver disease (NAFLD), and cardiovascular risk reduction

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Speeding was observed in 0.3% to 0.9% of responses

The article says the monthly figure is only one input

These participants were randomized to once-weekly subcutaneous retatrutide (1, 4, 8, or 12 mg) or placebo for 48 weeks

Those showing minimal early response may need dose adjustments, medication switching, or acknowledgment that their particular physiology responds less robustly to these receptor agonist approaches