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But plausibility is not proof, and a mechanism observed in a culture dish is not a clinical outcome measured on a human scalp

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In response to inflammatory mediators, ECs produce pro-inflammatory cytokines and chemokines such as IL-1, IL-6, CCL2, and CXCL1, and synthesize ICAM-1 and VCAM-1, facilitating the infiltration of immune cells [239]

The tissue becomes stiff, brittle, and prone to flare cycles

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