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As a border collie mix, Yuki may also have been a carrier for intestinal cobalamin (B12) malabsorption, the genetic mutation originally found in border collies

There are some nerves running through the shoulder and there is always a slight chance a needle may hit a nerve if the injection location is incorrect

Acute toxicity studies have failed to establish a lethal dose even at very high concentrations in rodents, a finding reported by the Sikiric group and referenced in several reviews