Moreover, after systemic administration, PROTACs may undergo substantial dilution and loss of effective exposure before reaching target cells due to circulation, tissue distribution, protein binding, metabolic clearance, and nonspecific uptake [4], further underscoring the need for efficient delivery systems
Three main mechanisms leading to hyperhomocysteinemia are these: (1) an inhibition of the homocysteine remethylation pathway dependent on folate or cobalamin deficiency, on the C677T mutation of MTHFR, or on the functional deficiency in methionine synthase
Ighodaro, O
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