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Primers 9:44

Two studies described target site resistance

The basic principle causing the radiation-induced toxicity is the excessive generation of reactive oxygen species (ROS) due to the radiolysis of cellular water, which in turn oxidizes the critical biomolecules such as lipid, protein, and DNA [36,37,38,39]

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As this is below the threshold of 100 claims for a service within a year, we proposed to again apply our universal low volume APC policy and use the highest of the geometric mean cost, arithmetic mean cost, or median cost based on up to 4 years of claims data to assign the service to the appropriate New Technology APC