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Autophagy can induce the secretion of immunosuppressive cytokines and regulate the expression of immune checkpoints such as PD-L1 (73)

A major complication of blood transfusion is hemolytic transfusion reactions that occur primarily in RBC alloimmunized patients and SCD patients, in particular, are at high risk because of the mismatch in donor pool (predominantly Northern European descent) while SCD patients are predominantly of African descent (Vichinsky et al., 1990