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Distinguishing local from systemic IGF-1 action A recurring theme in the muscle literature is that locally produced IGF-1 generated within the muscle in response to loading or expressed from a transgene appears especially effective at supporting hypertrophy and repair, potentially through autocrine and paracrine action on nearby satellite cells and fibers

Sahay ASK, Hill AS, OCarroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

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Higher absolute bioavailability for hydroxychalcone may be due to its higher tissue binding, high molecular weight, higher water solubility, and higher volume of distribution